The film is a fictional adaptation of his one-man Broadway show, "Ghetto Klown," which follows Leguizamo's journey to fame. The film stars Rosie Perez, Radha Mitchell, Griffin Dunne, Yul Vasquez, Tomas Milian and Ally Sheedy.
"I'm very honored to be working with 108 Media's honcho Mark Urman, who I have always looked up to in the independent scene," the actor said in a statement. "This was my first foray into screenwriting and in trying to up-end a format by making an anti-romantic comedy."
108 Media plans to open it this summer.