Shandling had a long career as a stand-up comedian, writer and performer in film and television, but perhaps his most lasting legacy will be the long-running HBO comedy "The Larry Sanders Show," which was ahead of its time in its depiction of the highly dysfunctional behind-the-scenes world of a late night talk shows. Running for six seasons, "Larry Sanders" set the bar for what comedy looked like in a premium cable world.
Over the course of his career, Shandling received 19 Emmy nominations, winning in 1998 for Outstanding Writing for a Comedy Series. He also directed several episodes of "Larry Sanders" and wrote and starred in the film "What Planet Are You From?"
In recent years, his appearances on screen had tapered off. Shandling’s last screen credit was as the duplicitous Senator Stern in "Captain America: Winter Soldier," but in 2016 he did spend some time with Jerry Seinfeld in a car, getting some coffee.