Follows a pair of married couples, Alfie (Hopkins) and Helena (Jones), and their daughter Sally (Watts) and husband Roy (Brolin), as their passions, ambitions, and anxieties lead them into trouble and out of their minds. After Alfie leaves Helena to pursue his lost youth and a free-spirited call girl named Charmaine (Punch), Helena abandons rationality and surrenders her life to the loopy advice of a charlatan fortune teller. Unhappy in her marriage, Sally develops a crush on her handsome art gallery owner boss, Greg (Banderas), while Roy, a novelist nervously awaiting the response to his latest manuscript, becomes moonstruck over Dia (Pinto), a mystery woman who catches his gaze through a nearby window.
Exactly 100 years after the Armenian Genocide in Ottoman Turkey, a mysterious director (Simon Abkarian) is staging a play at the Los Angeles Theatre to honor the victims of that tragedy – a horrifying crime forgotten and denied for an entire century. But as protesters surround his theatre, and a series of strange accidents spread panic among his producer (Jim Piddock) and actors (Angela Sarafyan, Sam Page, Nikolai Kinski), it appears that the director’s mission is profoundly dangerous, and the ghosts of the past are everywhere.