Dafoe reunites with Lars von Trier for the third time (after 2005's "Manderlay" and 2009's "Antichrist," which also starred "Nympho" cast member Gainsbourg). Kier, meanwhile, started working with Trier in 1988 in the film "Medea" and has since then starred in "Europe," "Breaking The Waves," "The Kingdom," "Dogville," "Manderlay" and "Melancholia."
The film is described as "the wild and poetic story of a woman’s erotic journey from birth to the age of 50 as told by the main character, the self-diagnosed nymphomaniac, Joe (Gainsbourg). On a cold winter’s evening the old, charming bachelor, Seligman (Skarsgård), finds Joe beaten up in an alley. He brings her home to his flat where he cares for her wounds while asking her about her life. He listens intently as Joe over the next 8 chapters recounts the lushly branched-out and multi faceted story of her life, rich in associations and interjecting incidents."
The film is produced by Louise Vesth for Zentropa Entertainments in co-production with Bettina Brokemper for Zentropa International Köln, Marianne Slot for Slot Machine and Bert Hamelinck for Caviar.