Emma Stone and Jonah Hill star as Annie Landsberg and Owen Milgrim in “Maniac.” The plot finds their two characters signing up for a drug trial which promises to remove their psychological pain.

Jonah Hill stars as Owen Milgrim in Netflix’s “Maniac.” 

Jonah Hill, Emma Stone, and the cast of “Maniac” in a scene depicting a phase of the drug trial. The patients are hooked up to a machine that transports their bodies into constructed realities, some of which include a suburban home and a fantasy odyssey in the vein of “Lord of the Rings.”

Emma Stone appears as Annie Landsberg in a scene from Netflix’s “Maniac.” This photo depicts Landsberg in one of the constructed realities. 

“Ozark” actress Julia Garner stars opposite Emma Stone in “Maniac.” 

Billy Magnussen, best known for roles in “Into the Woods” and “Game Night,” stars in “Maniac.”

Emma Stone and Jonah Hill play a suburban husband and wife in one of the constructed realities in “Maniac.”

Sally Field stars as Dr. Greta Mantleray in “Maniac.” The Oscar winner’s character is overseeing the drug trial at the center of the show’s plot. Her son, Dr. James K. Mantleray (Justin Theroux), is the head scientist in charge of the trial.

Gabriel Byrne’s character in “Maniac” remains a mystery for now. The actor’s role marks a return to television after his leading turn on HBO’s “In Treatment.”

Emma Stone and Jonah Hill in a scene from Netflix’s “Maniac.”

Justin Theroux and “Ex Machina” breakout Sonoya Mizuno star as Dr. James K. Mantleray and Dr. Fujita, respectively. The two scientists are running the drug trial.

Jonah Hill appears in a scene from Netflix’s “Maniac.”

Sally Field stars as Dr. Greta Mantleray in “Maniac.” 

Justin Theroux stars as Dr. James K. Mantleray in Netflix’s “Maniac.” The role marks a return to television for Theroux after spending three seasons on HBO’s “The Leftovers.”

Emma Stone and Jonah Hill star in Netflix’s “Maniac.” The film marks a reunion for the actors after “Superbad.”

Emma Stone and Jonah Hill star in Netflix’s “Maniac.”